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rifapentine will lower the extent or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.grapefruit will improve the level or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.By Melinda Smith, M.A. and Lawrence Robinson Are sleeping pills or snooze